antiviral genes – Communicable Diseases Research

More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro

Article

Published on 2022-11-012022-11-15
Journal: Virus research
[Category] SARS, 치료법, 치료제,

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

숙주와 SARS-CoV-2의 전투: 선천 면역과 바이러스 회피 전략

Review

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] activated Antiviral antiviral gene antiviral genes antiviral targets caused confirmed cases COVID-19 death Defense evade highlight Host host response immune immune evasion immune surveillance Immunity Inflammation Innate innate immune innate immune response innate immune system Innate immunity interferon interferons Invasion knowledge life cycle mechanism pathogen Pattern recognition pattern recognition receptor Pattern recognition receptors PRRs recognizing Replication restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Signaling signaling cascade signaling transduction. Surveillance transduction type I type I and III interferons viral life cycle viral spread
[DOI] 10.1016/j.ymthe.2022.02.014 PMC 바로가기 [Article Type] Review

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

프로게스테론에 의한 SARS-CoV-2를 포함한 바이러스에 대한 선천 면역 반응의 조절

Article

Published on 2022-04-252022-09-11
Journal: Signal Transduction and Targeted Therapy
[Category] COVID19(2023년), SARS, 변종, 치료제,

Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2

Article

Published on 2021-08-262022-10-31
Journal: Cells
[Category] COVID-19, MERS, SARS,

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

Resource and Technical Advance

Published on 2021-08-232022-10-30
Journal: JCI Insight
[Category] COVID-19, SARS,

[키워드] ACE2 ACE2 expression AIDS/HIV analyzed antiviral genes antiviral response canonical cause change chronic controls COVID-19 disease severity downregulation Enterocyte epithelial cell expression fatality GI Tract Gut highest HIV infection homeostasis impair increased risk individual individuals infect Innate immunity interferon response interferon signaling intestinal lymphoid mucosal Prevent Protein reduction SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 receptor single-cell small intestine Symptoms target cell target cells tissue TMPRSS2 TMPRSS4 transcriptional profile treated uninfected upregulation vaccine response
[DOI] 10.1172/jci.insight.148920 PMC 바로가기 [Article Type] Resource and Technical Advance

Differentially expressed immune response genes in COVID-19 patients based on disease severity

질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자

Research Paper

Published on 2021-04-152022-09-10
Journal: Aging (Albany NY)
[Category] SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated
[DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper

Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10

Research Articles

Published on 2018-09-212022-10-28
Journal: Bioscience Reports
[Category] Coronavirus,

[키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used
[DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

Research Article

Published on 2017-06-022022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus virus infection viruses
[DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Standard

Published on 2013-08-012022-10-30
Journal: The Journal of General Virology
[Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome Alpha Antiviral compound antiviral genes Cell culture cell lines cellular Characteristics characterized consequence CoV CoVs cyclosporin A cytotoxicity develop disease electron microscopy expression found highlight Human humans identify IFN-α implicated implication in vitro induce Infected Infection infectious inhibit inhibited inhibitor innate immune response Interaction interferon Interferon-α membrane membranes MERS-CoV MERS-CoV infection MERS-CoV-infected patients Middle East nuclear translocation observation outbreak outcome phosphorylated Prevent progeny related Replication respiratory RNA synthesis SARS-CoV Stat1 titre Treatment Vero Cell Vesicle viral RNA synthesis was used were used zoonotic CoV
[DOI] 10.1099/vir.0.052910-0 PMC 바로가기 [Article Type] Standard

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별

Research Article

Published on 2011-12-012022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene
[DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article